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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by deli on June 4, 2006, at 18:34:21
I was just wondering if anyone has felt better after taking anti-inflammatory drug (Celebrex). About 5 days ago my dr. prescribed some Celebrex for my shoulder and a muscle relaxant. That night I slept for 12 hours and when I woke up I felt better than I have felt in a long time. I continued taking it for 3 days and then stopped since the pain had subsided. A day or two later, I began feeling down and exhausted again. The only thing that had changed was that I stopped the anti-inflammatory med. Could there possibly be a link between depression and inflammation of the body in general and anti-imflammatory medication can be of help? What does anyone think?
Posted by SLS on June 4, 2006, at 19:43:47
In reply to anti-inflammatories and depression, posted by deli on June 4, 2006, at 18:34:21
> I was just wondering if anyone has felt better after taking anti-inflammatory drug (Celebrex). About 5 days ago my dr. prescribed some Celebrex for my shoulder and a muscle relaxant. That night I slept for 12 hours and when I woke up I felt better than I have felt in a long time. I continued taking it for 3 days and then stopped since the pain had subsided. A day or two later, I began feeling down and exhausted again. The only thing that had changed was that I stopped the anti-inflammatory med. Could there possibly be a link between depression and inflammation of the body in general and anti-imflammatory medication can be of help? What does anyone think?
Some researchers have noted an association between elevated levels of markers for inflammation and depression. It has been reported that CoX-2 inhibitors can improve depression is some individuals.
I once tried doxycycline as a treatment for depression. One of the rationales for trying doxycycline is that it acts as an anti-inflammatory in the brain.
- Scott
Posted by deli on June 4, 2006, at 20:58:13
In reply to Re: anti-inflammatories and depression, posted by SLS on June 4, 2006, at 19:43:47
you for your reply. You mentioned that you tried this type of therapy once. Why did you stop? Did it not work?
I also found this article which sounds pretty interesting.
www.biopsychiatry.com/immunesystem/index.html
Posted by SLS on June 4, 2006, at 21:07:40
In reply to Re: anti-inflammatories and depression, posted by deli on June 4, 2006, at 20:58:13
> you for your reply. You mentioned that you tried this type of therapy once. Why did you stop? Did it not work?
>
> I also found this article which sounds pretty interesting.
>
>
> www.biopsychiatry.com/immunesystem/index.html
Thanks for the citation.I took doxycycline for about three months. It wasn't helping, so I discontinued it.
- Scott
Posted by Phillipa on June 4, 2006, at 21:52:06
In reply to Re: anti-inflammatories and depression, posted by SLS on June 4, 2006, at 19:43:47
Scott how strange I alwsys feel better on antibiotics but thought it was the infection going away. Love Phillipa
Posted by linkadge on June 5, 2006, at 15:06:25
In reply to Re: anti-inflammatories and depression » SLS, posted by Phillipa on June 4, 2006, at 21:52:06
I actually think there are a few clinical trials that used celebrex as an adjunctive to antidepressants. I will try to find those studies.
Certain forms of inflammation apear to make certain people very depressed. Interleuken-1 has been suspected. I also think that Interleuken-6 has been suspected.
Certain inflamintory pathways travel through limbic systems. In the case of chemotherapy induced depression, interleuken-1 appears to reduce the conversion of trypophan to serotonin.
You can make certain people very suicidal very quickly by altering certain inflamitory pathways.In addition, inflamation supresses neurogenesis. So if, for whatever reason the immune system is out of whack, this could translate to poor hippocampal proliferation, and depresison.
Don't discount your experiences.
Linkadge
Posted by janeB on June 5, 2006, at 20:10:20
In reply to anti-inflammatories and depression, posted by deli on June 4, 2006, at 18:34:21
I had the opposite reaction to anti inflammatories. All NSAIDs seem to make me depressed--Celebrex, Lodine, Ibuprofen, etc. Now I have to stick with tylenol which doesn't really help with the inflammation, just helps pain. Then with pain reduced activity increases and inflammation seems to subside.
We are all react so differently to meds. Jane
Posted by Caedmon on June 5, 2006, at 20:30:10
In reply to Re: anti-inflammatories and depression, posted by linkadge on June 5, 2006, at 15:06:25
I believe that omega-3 fatty acids have anti-inflammatory properties.
http://www.jacn.org/cgi/content/full/21/6/495
What do you guys think - possible mechanism of action in mood?
- Chris
Posted by deli on June 5, 2006, at 21:07:10
In reply to Re: anti-inflammatories and depression, posted by linkadge on June 5, 2006, at 15:06:25
> I actually think there are a few clinical trials that used celebrex as an adjunctive to antidepressants. I will try to find those studies.
>
> Certain forms of inflammation apear to make certain people very depressed. Interleuken-1 has been suspected. I also think that Interleuken-6 has been suspected.
>
> Certain inflamintory pathways travel through limbic systems. In the case of chemotherapy induced depression, interleuken-1 appears to reduce the conversion of trypophan to serotonin.
> You can make certain people very suicidal very quickly by altering certain inflamitory pathways.
>
> In addition, inflamation supresses neurogenesis. So if, for whatever reason the immune system is out of whack, this could translate to poor hippocampal proliferation, and depresison.
>
> Don't discount your experiences.
>
> Linkadge
>Hello Linkadge,
Thank you for your reply.I have suffered with this illness for so many years making me very sensitive to any change in mood, especially when I feel the slightest elevation in mood. Gosh, is just such a good feeling. I know this might just be coincidental but you are right I shouldn't discount anything.
Greetings,
Deli
Posted by deli on June 5, 2006, at 21:25:36
In reply to Re: anti-inflammatories and depression » deli, posted by janeB on June 5, 2006, at 20:10:20
> I had the opposite reaction to anti inflammatories. All NSAIDs seem to make me depressed--Celebrex, Lodine, Ibuprofen, etc. Now I have to stick with tylenol which doesn't really help with the inflammation, just helps pain. Then with pain reduced activity increases and inflammation seems to subside.
> We are all react so differently to meds. JaneHello Jane,
I did't notice this with neither ibuprofen, Aleve,or Vioxx but only with Celebrex. Of course this might just be coincidental and I just felt better regardless of taking Celebrex, but the change in mood felt different than in other ocassions.
You are so right. All of us react so differently to meds and probably it may be that our depression stems from unknown, not yet discovered conditions that require different modes of therapy. Who knows?Greetings,
Deli
Posted by Declan on June 7, 2006, at 13:54:35
In reply to Re: anti-inflammatories and depression, posted by deli on June 5, 2006, at 21:07:10
NSAIDs are protective against Alzheimers? LEF puts fractions of Boswellia and tangeretin and nobelitin in Cognitex to block the inflammatory pathways, but it didn't cheer me up either.
Posted by neuroman on June 12, 2006, at 17:01:35
In reply to Re: anti-inflammatories and depression, posted by Declan on June 7, 2006, at 13:54:35
I guess I'm a little late jumping into this thread, but I've been reading a lot about this lately. When I stopped Elavil after being on it for three and a half years my health really went down the toilet. Not only did the original neuropathic pain that led me to take Elavil come back, but all kinds of other pain. I felt like I was dying. Since stopping it I've suffered from chronic pelvic pain, genito-urinary pain and a mild irritable bowel type syndrome. Of course the original neuropathic pain in my left foot also returned worse than before.
Blood tests after stopping Elavil showed an elevated sedimentation rate. Something I didn't have prior to taking it. Over the past couple of years I've managed to make something of a comeback thanks to DLPA, tyrosine, antioxidants and EFA's. I'm still a long way from healthy though. I've also tried a couple of meds since stopping Elavil. One of which was bupropion SR. With the first dose of this med I felt a lot of pain relief. I assumed it was the increased NE transmission, but I've read that bupropion is a fairly powerful anti-infammatory. It lowers TNF-a and IL-1 and raises IL-10, which is an anti-inflammatory. I'm beginning to wonder if the efficacy of the antidepresants I've taken has less to do with boosting monoamines and more to do with fighting inflammation. It turns out that most antidepressants, regardless of class, are fairly potent anti-infammatories. This may be something to consider, particularly in those individuals whose depression is accompanied by somatic complaints. It probably has to do with both, since TNF effects NE neurotransmission anyway.
In any event, I'm wondering if a low dose of bupropion or a NE specific tricyclic like desipramine might be a good choice for someone like me. That is, someone who has had fatigue and pain along with depression. (In fact, I've always felt the fatigue and pain have been the cause of my depression.) I'm reluctant to try any of the "broad spectrum" TCAs anymore. (In many respects I guess all TCAs are "broad spectrum".) For the most part I've been med free for the last couple of years but I feel like its been a constant struggle to keep my head above water. It sure as heck hasn't been living. Just surviving. Maybe someday they'll finally figure out how these friggin' meds actually work...
Paul
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