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Re: anti-inflammatories and depression

Posted by linkadge on June 5, 2006, at 15:06:25

In reply to Re: anti-inflammatories and depression » SLS, posted by Phillipa on June 4, 2006, at 21:52:06

I actually think there are a few clinical trials that used celebrex as an adjunctive to antidepressants. I will try to find those studies.

Certain forms of inflammation apear to make certain people very depressed. Interleuken-1 has been suspected. I also think that Interleuken-6 has been suspected.

Certain inflamintory pathways travel through limbic systems. In the case of chemotherapy induced depression, interleuken-1 appears to reduce the conversion of trypophan to serotonin.
You can make certain people very suicidal very quickly by altering certain inflamitory pathways.

In addition, inflamation supresses neurogenesis. So if, for whatever reason the immune system is out of whack, this could translate to poor hippocampal proliferation, and depresison.

Don't discount your experiences.

Linkadge


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