Posted by deli on June 5, 2006, at 21:07:10
In reply to Re: anti-inflammatories and depression, posted by linkadge on June 5, 2006, at 15:06:25
> I actually think there are a few clinical trials that used celebrex as an adjunctive to antidepressants. I will try to find those studies.
>
> Certain forms of inflammation apear to make certain people very depressed. Interleuken-1 has been suspected. I also think that Interleuken-6 has been suspected.
>
> Certain inflamintory pathways travel through limbic systems. In the case of chemotherapy induced depression, interleuken-1 appears to reduce the conversion of trypophan to serotonin.
> You can make certain people very suicidal very quickly by altering certain inflamitory pathways.
>
> In addition, inflamation supresses neurogenesis. So if, for whatever reason the immune system is out of whack, this could translate to poor hippocampal proliferation, and depresison.
>
> Don't discount your experiences.
>
> Linkadge
>Hello Linkadge,
Thank you for your reply.I have suffered with this illness for so many years making me very sensitive to any change in mood, especially when I feel the slightest elevation in mood. Gosh, is just such a good feeling. I know this might just be coincidental but you are right I shouldn't discount anything.
Greetings,
Deli
poster:deli
thread:652899
URL: http://www.dr-bob.org/babble/20060604/msgs/653403.html