![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by rjk on July 13, 2002, at 8:46:26
Antidepressants, or rather combining Effexor and Remeron, have wrecked my life. My brain is now so sensitive to any form of chemical that I lierally cannot even take paracetamol.
I am sure that many people have had success with combining drugs, but I just wish that psychiatrists took a bit more of a responsible attitude about diagnosing peoples condition, particularly when it comes to combining medication.
I recently read a comment that someone had written about the way psychiatrists dole out drugs,"when you have a hammer in your hand, everything looks like a nail". How true that is!
Posted by Lou Pilder on July 13, 2002, at 10:00:54
In reply to How Safe Are Antidepressants?, posted by rjk on July 13, 2002, at 8:46:26
rjk,
You asked how safe Ads were. I was given a tricyclic antidepressant (desipramine) and after 5 or 6 days I began to hear a song on my head. The music is not pleasent. I now hear music 24/7 and there is no proven treatment for this disorder.
I have received reports from the FDA by using the freedom of infomation act and have a collection of adverse reactions to just that drug that is lenghthly. You can key in "psychotropic drugs, adverse reactions" and start with that to answer your question as to how safe theses drugs are. Or key in "antidepressants, harmfull" or some other phrase that is similar to that.
There are Drs. that speak out against these drugs. Peter Bregin being one of them. You could also key in,"thoery of chemical imbalance, quackery" and go from there. You could also key in," Psychiatry, quackery" and go from there. You could also key in ,"neuroleptic malignant syndrome" and go from there. You could also key in,"antidepressants, movement disorders" or TD.
You could also key in,"psychotropic drugs, deaths". I hope that I have given you some infomation that you can use to make an informed decision as to how safe ADs are.
Lou
Posted by Geezer on July 13, 2002, at 14:08:16
In reply to Re: How Safe Are Antidepressants? » rjk, posted by Lou Pilder on July 13, 2002, at 10:00:54
Anyone have a reference about the 15-20% suicide rate for depressed patients who don't take psycotropic drugs?
Geezer
Posted by Shawn. T. on July 13, 2002, at 15:14:29
In reply to How Safe Are Antidepressants?, posted by rjk on July 13, 2002, at 8:46:26
I am definitely beginning to think that there is something not good about mixing Effexor and Remeron. I have recently read similar reports to your own. Dosages required to achieve noradrenaline (norepinephrine) increases with Effexor are much too high. See
http://www.gpcr.org/7tm/ligand/Organon/Tablig/LIG_C93413695.htmlEvery single one of those values is in the ineffective range!!!
Posted by Shawn. T. on July 13, 2002, at 16:41:49
In reply to How safe is Effexor, specifically with Remeron?, posted by Shawn. T. on July 13, 2002, at 15:14:29
I should definitely mention that Effexor is a potent serotonin reuptake inhibitor. You have to take more than 300mg/day to achieve noradrenaline reuptake inhibition by the way.
Posted by turalizz on July 13, 2002, at 16:55:29
In reply to Re: How safe is Effexor, specifically with Remeron?, posted by Shawn. T. on July 13, 2002, at 16:41:49
> I should definitely mention that Effexor is a potent serotonin reuptake inhibitor. You have to take more than 300mg/day to achieve noradrenaline reuptake inhibition by the way.
Exactly! Six months ago, I started an effexor trial instead of reboxetine, because I thought I would be better off with a 5ht AND NE reuptake inhibitor instead of just NE.
I went up to 300mg, and then realised that its declared NE reuptake property was totally a joke. (At least within the recommended dose range.)
In the end I was right about my feeling that noradrenergic antidepressants would help me (mianserin and reboxetine helped me a lot), but I lost 3 months and went into terrible withdral from damn effexor.
I hate Wyeth and Effexor! (just my subjective feeling :)
cem
Posted by Shawn. T. on July 13, 2002, at 18:05:42
In reply to Re: How safe is Effexor, specifically with Remeron? » Shawn. T., posted by turalizz on July 13, 2002, at 16:55:29
Thanks for the comments. I'm fond of mianserin as well, but I'm not very well read on it. I am also fond of reboxetine to a certain degree.
See
http://www.biopsychiatry.com/mianserin.htm
and
http://biopsychiatry.com/nordop.htm
and
http://reboxetine.com/
As a side note, I'm becoming more and more convinced that Wellbutrin's effect on dopamine reuptake is perhaps entirely due to an increased level of noradrenaline in the brain. One of Wellbutrin's metabolites, hydroxybupropion, is a rather potent noradrenaline reuptake inhibitor. I'd like to suggest that perhaps Wellbutrin was perhaps the first selective noradrenaline reuptake inhibitor. Anyone agree/disagree that can provide some proof? I'd love to hear from someone that has taken both reboxetine and Wellbutrin.
Posted by rjk on July 14, 2002, at 2:26:16
In reply to How safe is Effexor, specifically with Remeron?, posted by Shawn. T. on July 13, 2002, at 15:14:29
Shawn,
I would be very interested to know where you have read about similar experiences to mine.
Regards
Richard> I am definitely beginning to think that there is something not good about mixing Effexor and Remeron. I have recently read similar reports to your own. Dosages required to achieve noradrenaline (norepinephrine) increases with Effexor are much too high. See
> http://www.gpcr.org/7tm/ligand/Organon/Tablig/LIG_C93413695.html
>
> Every single one of those values is in the ineffective range!!!
Posted by rjk on July 14, 2002, at 2:30:47
In reply to Re: How safe is Effexor, specifically with Remeron?, posted by Shawn. T. on July 13, 2002, at 16:41:49
That all sounds very technical. What does it actually mean (for a dummy like me)?
> I should definitely mention that Effexor is a potent serotonin reuptake inhibitor. You have to take more than 300mg/day to achieve noradrenaline reuptake inhibition by the way.
Posted by Geezer on July 14, 2002, at 10:06:24
In reply to How Safe Are Antidepressants?, posted by rjk on July 13, 2002, at 8:46:26
rjk,
Hopefully some of this problem will be resolved when Lilley releases Duloxatin (sp). According to reports Duloxatin has a 50% - 50% effect. This would indicate to me the drug causes an equal effect on norep. and serotonin receptors.....beginning with the first dose.
I contacted Lilley as recently as 2 weeks ago. They say their "target date" for release is 2003. All phase testing on the drug has been completed, the only delay at this point is the FDA/Gestapo.
I would have to agree with you, the combination of Effexor and Remeron means you have to wade through too much serotonin effect to get to the norep. (if infact that is what you are seeking).
There are others here able to give a much better review of the chemistry than I.You might want to go out on the net and do a search on Duloxatin (check if I have the spelling correct) then come back to pbabble and do a search.
Best wishes,
Geezer
Posted by oracle on July 15, 2002, at 11:50:42
In reply to Re: How safe is Effexor, specifically with Remeron?, posted by Shawn. T. on July 13, 2002, at 16:41:49
No problems
Posted by rjk on July 17, 2002, at 13:39:45
In reply to I have taken Remeron+Effexor for 7 years, posted by oracle on July 15, 2002, at 11:50:42
> No problems
Wish I could say the same
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.