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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by mmcconathy on January 22, 2005, at 13:01:59
I have lowered my dose down from adderall from 60mg to 40mg.
I took 60mg daily in one dose, which was effective, but i belive was just too high generally.
I started noticing more slowing, and exhaustion daily, which was not normal for a medication, I was prescribed to only take it once daily, but i did abuse and another dose after the other, that totally was 120mg daily.
I regret my stupidity, but i used it for school, then after that I would have to do very complicated work at my dad's office, which i usally took the second dose.
I have read amphetamine causes destruction to dopamine terminals (nuerotoxity) after daily doses, at high doses.
I pray that they will restore, and want to kill my self what i have done.
Please help me, and tell me anything.
Matt
Posted by mmcconathy on January 22, 2005, at 13:22:40
In reply to Maxime, i need your advice for nuerontoxity, posted by mmcconathy on January 22, 2005, at 13:01:59
this is also why i took my dad's presciption barbiturate, Pentobarbital, which he had forgotten about, becuase it produced horrible insomnia.
Even after it wore off usally at about 7:00pm, i would close my eyes and stay awake the rest of the night, this made me go in violent rages.
I would usally only 1, which did give me ok sleep.
I know, know, know how horrible of a routine that was, but i know the result of it.
Do you know if nuerons will restore?
God Bless
Matt
Posted by SLS on January 22, 2005, at 14:45:18
In reply to Maxime, i need your advice for nuerontoxity, posted by mmcconathy on January 22, 2005, at 13:01:59
Hi.
Where did you get the idea that normal amphetamine produces neurotoxicity? It is the serotonergic derivatives of amphetamine that are known to be neurotoxic.
I don't think you have anything to worry about. Set your mind at ease.
- Scott
Posted by mmcconathy on January 22, 2005, at 15:08:33
In reply to Maxime, i need your advice for nuerontoxity, posted by mmcconathy on January 22, 2005, at 13:01:59
destruction to dopamine nuerons.
Methamphetamine is known more for this, but still Amphetamine is similar to it.
Thanks anyways.
Posted by Maxime on January 22, 2005, at 15:27:16
In reply to Maxime, i need your advice for nuerontoxity, posted by mmcconathy on January 22, 2005, at 13:01:59
Hi,
Oddly enough, SSRI have been shown to repair any damage. There are so many meds we all take on this board that can cause neotoxity and we don't have to abuse them for it to happen. Wellbutrin can cause neurotoxity.
If you are really concerned have some blood tests done and see how your liver and pancreas are functioning. The symptoms you have could be symptoms of depression. Also, get your thyroid checked (simple blood test).
Don't be angry at yourself. Use that energy to focus on getting well and feeling better.
I went through neurotoxity syndrome (worse than neurotoxity) twice as the results of overdoses (suicide attempts). I took 8000 mg of Parnate once and 4200 mg of Effexor. The parnate damaged my pancreas permanently but all cognitive problems were restored (thank God). The last thing I rememeber is my temperature went up to 105 degrees. After the Effexor I had multiple seizures and could not walk or talk for 3 weeks. Luckily everything came back and I actually completed my Phd.
So don't worry about what might be. Get some blood tests done. See a neurologist if you feel you need to. You don't want to fuel your anxiety with anxiety.
Let us know what you decide to do and take care of yourself.
Maxime
PS. Congrats on lowering your Adderall dosage.
> I have lowered my dose down from adderall from 60mg to 40mg.
>
> I took 60mg daily in one dose, which was effective, but i belive was just too high generally.
>
> I started noticing more slowing, and exhaustion daily, which was not normal for a medication, I was prescribed to only take it once daily, but i did abuse and another dose after the other, that totally was 120mg daily.
>
> I regret my stupidity, but i used it for school, then after that I would have to do very complicated work at my dad's office, which i usally took the second dose.
>
> I have read amphetamine causes destruction to dopamine terminals (nuerotoxity) after daily doses, at high doses.
>
> I pray that they will restore, and want to kill my self what i have done.
>
> Please help me, and tell me anything.
>
> Matt
Posted by linkadge on January 22, 2005, at 16:25:04
In reply to Re: Maxime, i need your advice for nuerontoxity, posted by Maxime on January 22, 2005, at 15:27:16
You really don't need to worry for multiple reasons.
1) Even 120mg is not a toxic dose, by any
strech of the imagination. The doses used
to produce toxicity in mice were more like
120mg (per kilogram!) of body weight.2) The serotogenic neurons and dopaminergic
neurons can (and do) repair themselves. As
well, new neurons grow on a daily basis.
For insance, BDNF is a growth factor that is
increased by physical exercise (jogging)
that growth factor is trophic to the
serotogenic system. BDNF injections literally
grow new serotogenic neurons. Similar growth
factors exist for other neurotransmitter
systems. Omega 3 is trophic to serotogenic and
dopaminergic systems.3) It seems to me that you are depressed now, and
you were depressed even before this
neurotoxicity issue even came up. Your best
bet, it to first get the depression under
control. Forget about this issue and first
determine if you meet the criteria for
depression. Get your depression under controll.4) Paridoxically, stimulants can cause depression
*unrelated to weather or not they are
neurotoxic*.Take Care
Linkadge
Posted by mmcconathy on January 22, 2005, at 20:56:02
In reply to Re: Maxime, i need your advice for nuerontoxity, posted by mmcconathy on January 22, 2005, at 13:22:40
I've been schedueled for a blood test next week, actually, last time my mom called in, asked if taking medication would interfere, they said no.
WHen we got out there, they asked if i take any vitimens, which i do, they said it would have to be rescheuduled for 7 days. Inconvienince!
I had an EEG, i already see a nuerologist, which the readings where sent to him, since it was at a diffrent medical center. Wont here about that for a week.
I may have an MRI soon, becuase he said we would talk after he got the readings.
I never posted this, but once when adderall wore off, about 30min after i had tingling feelings all out throught my body, after that i thought i was having a heart attack, a feeling disconnection with reality since then has persisted, hyperventilation, my hands started turing light blue, i could not even get to the phone without feeling i was going to collapse, i laid in my bed praying for it leave for about 10min, after that, i was better but exhasted.
My therpist has described that both of these sound like dissociative symptoms, which results from trauma, but usally expereinced trauma like rape, murder, war, abuse. Mainly that is why im getting a MRI to see if any abnormal change has taken form.
I soon may terminate adderall, i dont feel good with staying with it for now, until the reading will show no lesions or abnormalites.
Anyways, i will keep you posted about the reading results.
Thanks for your advice
Matt
This is the end of the thread.
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