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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by bampf on December 3, 2002, at 5:41:08
I read some psychpharm. research indicating Wellbutrin has an affinity for mostly norepinephrine and serotonin and very little for dopamine. Is this not a fact? or can these neurotransmitter levels vary depending on the person. I tried Wellbutrin briefly but it made me anxious and "crazy". However, I've heard of its use for adult ADD with good results.
Any comments?????
Posted by Larry Hoover on December 3, 2002, at 8:33:43
In reply to Anyone w/ good psychopharm. research knowledge??, posted by bampf on December 3, 2002, at 5:41:08
> I read some psychpharm. research indicating Wellbutrin has an affinity for mostly norepinephrine and serotonin and very little for dopamine. Is this not a fact? or can these neurotransmitter levels vary depending on the person.
Receptor number and sensitivity will vary from person to person. Buproprion has some reuptake inhibition for norepinephrine and serotonin, but its highest affinity is for the dopamine transporter.
>I tried Wellbutrin briefly but it made me anxious and "crazy". However, I've heard of its use for adult ADD with good results.
> Any comments?????Buproprion has higher affinity for the DA transporter than d-amphetamine (Adderal), but less than methylphenidate. I suppose that might make it a candidate for treatment of ADD, but individual differences in receptor number and sensitivity can easily over-rule theoretical considerations.
Posted by djmmm on December 3, 2002, at 12:00:58
In reply to Anyone w/ good psychopharm. research knowledge??, posted by bampf on December 3, 2002, at 5:41:08
Bupropion has very little affinity for serotonin, in fact, it isn't a very potent/selective drug at all. I beleive it acts mostly as a dopamine antagonist, whereas the metabolites (it has 3 major metabolites) are considered "potent" inhibitors of norepinephrine reuptake.
As far as it being more potent than d-amphetamine, I haven't heard this, I do know that the SSRI Zoloft is a more potent blocker of dopamine reuptake than wellbutrin...
Posted by Larry Hoover on December 3, 2002, at 12:11:24
In reply to Re: Anyone w/ good psychopharm. research knowledge??, posted by djmmm on December 3, 2002, at 12:00:58
> Bupropion has very little affinity for serotonin, in fact, it isn't a very potent/selective drug at all. I beleive it acts mostly as a dopamine antagonist, whereas the metabolites (it has 3 major metabolites) are considered "potent" inhibitors of norepinephrine reuptake.
>
> As far as it being more potent than d-amphetamine, I haven't heard this, I do know that the SSRI Zoloft is a more potent blocker of dopamine reuptake than wellbutrin...I'm not equating binding affinity to potency, but this is the reference I used:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8245956&dopt=Abstract
"Competition by ligands known to bind to the dopamine transporter showed a rank order of RTI-55 > GBR-12909 > maxindol > WIN 35428 > = methylphenidate > (-)-cocaine > buproprion > (+)-amphetamine."
Posted by pelorojo on December 5, 2002, at 12:22:14
In reply to Re: Anyone w/ good psychopharm. research knowledge??, posted by Larry Hoover on December 3, 2002, at 12:11:24
I've read that the main actions of bupropion come not from the drug itself but its metabolites and that those have the greatest effect on norepinephrine. Somewhere on the "Good Drug Guide" on hedweb it says that bupropion mildly antagonizes the release and mildy inhibits the uptake of dopamine. I believe it is Preskorn (preskorn.com?) that says that bupropion's actions come from its metabolites and that those primarily raise NE via reuptake inhibition.
I have sociology and business degrees (nothing scientific) and a wildly variant memory when it comes to these things so take these statements with a big grain of salt!
This is the end of the thread.
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