Posted by Larry Hoover on December 3, 2002, at 12:11:24
In reply to Re: Anyone w/ good psychopharm. research knowledge??, posted by djmmm on December 3, 2002, at 12:00:58
> Bupropion has very little affinity for serotonin, in fact, it isn't a very potent/selective drug at all. I beleive it acts mostly as a dopamine antagonist, whereas the metabolites (it has 3 major metabolites) are considered "potent" inhibitors of norepinephrine reuptake.
>
> As far as it being more potent than d-amphetamine, I haven't heard this, I do know that the SSRI Zoloft is a more potent blocker of dopamine reuptake than wellbutrin...I'm not equating binding affinity to potency, but this is the reference I used:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8245956&dopt=Abstract
"Competition by ligands known to bind to the dopamine transporter showed a rank order of RTI-55 > GBR-12909 > maxindol > WIN 35428 > = methylphenidate > (-)-cocaine > buproprion > (+)-amphetamine."
poster:Larry Hoover
thread:130355
URL: http://www.dr-bob.org/babble/20021203/msgs/130401.html