Posted by pelorojo on December 5, 2002, at 12:22:14
In reply to Re: Anyone w/ good psychopharm. research knowledge??, posted by Larry Hoover on December 3, 2002, at 12:11:24
I've read that the main actions of bupropion come not from the drug itself but its metabolites and that those have the greatest effect on norepinephrine. Somewhere on the "Good Drug Guide" on hedweb it says that bupropion mildly antagonizes the release and mildy inhibits the uptake of dopamine. I believe it is Preskorn (preskorn.com?) that says that bupropion's actions come from its metabolites and that those primarily raise NE via reuptake inhibition.
I have sociology and business degrees (nothing scientific) and a wildly variant memory when it comes to these things so take these statements with a big grain of salt!
poster:pelorojo
thread:130355
URL: http://www.dr-bob.org/babble/20021203/msgs/130651.html