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Re: Anyone w/ good psychopharm. research knowledge??

Posted by Larry Hoover on December 3, 2002, at 8:33:43

In reply to Anyone w/ good psychopharm. research knowledge??, posted by bampf on December 3, 2002, at 5:41:08

> I read some psychpharm. research indicating Wellbutrin has an affinity for mostly norepinephrine and serotonin and very little for dopamine. Is this not a fact? or can these neurotransmitter levels vary depending on the person.

Receptor number and sensitivity will vary from person to person. Buproprion has some reuptake inhibition for norepinephrine and serotonin, but its highest affinity is for the dopamine transporter.

>I tried Wellbutrin briefly but it made me anxious and "crazy". However, I've heard of its use for adult ADD with good results.
> Any comments?????

Buproprion has higher affinity for the DA transporter than d-amphetamine (Adderal), but less than methylphenidate. I suppose that might make it a candidate for treatment of ADD, but individual differences in receptor number and sensitivity can easily over-rule theoretical considerations.

 

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poster:Larry Hoover thread:130355
URL: http://www.dr-bob.org/babble/20021203/msgs/130367.html