Posted by Larry Hoover on May 8, 2005, at 9:12:06
In reply to Ugh -- ketamine vacuoles, Olney's Lesions » Larry Hoover, posted by AMD on May 7, 2005, at 21:17:31
> Would one bump of K be enough to trigger "Olney's Lesions" or the vaculoes seen in rats?
Virtually impossible.
> Also, I forgot in my last post to state that I'm taking Lamictal, Celexa, and had Seroquel about 8-10 hours after first going to bed in order to get more sleep. Did these drugs exasperate or block the K's effects?
Exacerbate. No.
> Just what I need. Now I'm going to be walking around imaging little holes in my cells, and think I have brain damage. Ugh!
>
> amdOlney's Lesions are also associated with another NMDA blocker, dextromethorphan.
The lesions are likely caused by chronic excessive doses.
In a single acute exposure to a toxicant, there is an injury threshold. Your body can take a tiny bit, with no problem. More, and the biochemical stressors increase along with it. At some point, the stress meets the capacity of the system to manage that stress. Any dose beyond that will cause damage.
The problem with chronic exposure is that it can do two things. It can constantly deplete the biochemical resources of the cells, preventing them, in effect, from stockpiling the safety equipment they would otherwise store. And, it can disturb regulatory systems in the cell, up- or down-regulating cell function.
Then, it is possible that low chronic doses routinely exceed the toxic threshold (cell injury), or that acute exposures at lesser doses than that single dose example above exceed the toxic threshold. You now have the setting for permanent injury from both acute and chronic exposures.
I strongly advise you seek out substance abuse counselling. There is some really good counselling out there (and some crap, too). You need to understand what it is that you gain from doing these drug binges. However it is that you process your experiences, the pain of continuing on with the drugs is still less than the pain of changing. Counselling can help you put your finger on the balance, tipping your decisions in one way, and one way only. Then, you can consciously find ways to provide safe substitutes for those things drugs once gave you. If you can satisfy those needs, you won't want drugs to meet them.
Best,
Lar
poster:Larry Hoover
thread:492031
URL: http://www.dr-bob.org/babble/subs/20050506/msgs/495147.html