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Re: 5HT2A is good! CrAzYmEd

Posted by Conundrum on May 29, 2010, at 11:20:32

In reply to Re: 5HT2A is good!, posted by CrAzYmEd on May 29, 2010, at 11:08:55

Well I agree that my subjective experiences are indeed different. When I *first* took prozac years ago it was awesome. I always felt good. If someone I know felt bad I recommended them taking it. I eventually stopped it since I thought I didn't need it. Bad call. Now any increase in serotonin makes me apathetic. So I'd say, yes, in a drug niave person it will probably increase dopamine along with norepinephrine via 5 HT2C antagonism. BTW prozac is a 5 HT2A antagonist according to Lilly's scientists, which about the same binding affinity as the 5HT2C receptor. There may be differences in the actual potency to block electrical signals, since there isn't much written about fluoxetine's actions at the 5HT2a receptor.

http://www.nature.com/npp/journal/v27/n6/full/1395967a.html


Post-SSRI syndrome: iatrogenic anhedonia, memory and concentration problems, sexual dysfunction. [NOTE no sadness or anxiety]
Location:USA
Currently taking 25mg Lamictal.

 

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poster:Conundrum thread:948688
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/949383.html