Posted by Conundrum on May 29, 2010, at 10:50:27
In reply to 5HT2A is good!, posted by CrAzYmEd on May 29, 2010, at 9:10:03
Interesting thread. Albeit kind of useless. First of all a lot of studies are done with rats, and humans do react different. Second my own experience with prozac reflects what Brainbeard said. At low doses I feel motivated on fluoxetine. As the dose is increased I no longer want to eat. Something has changed with the 5 HT2C receptor. For some people 5 HT2C antagonism is great. However many people don't do well on prozac because for them it causes anxiety. They do better on other SSRIs. So no matter how much you read you won't know how you will react to it.
Third, drugs like nefazodone and protriptyline increase sexual functioning while SSRIs that activate the 5-HT2A receptor cause a decrease in sexual functioning. Another thing is that after chronic use the effect on 5-HT2A receptors changes. Initially 5-HT2A blockade decrease norepinephrine, but after chronic dosing it returns to normal, but is less
Read the side effects. Increased sexual activation rather than decreased.
So I do believe that 5 HT2A agonism probably increases dopamine in certain areas of the brain, but most people won't be happy with the side effects.
I know that nothing I've said here is particularly scientific but I think its important to look at the actual effect in humans. Also I gotta go.
Finally, wouldn't a true agonist cause people to hallucinate?
Post-SSRI syndrome: iatrogenic anhedonia, memory and concentration problems, sexual dysfunction. [NOTE no sadness or anxiety]
Currently taking 25mg Lamictal.