Posted by CrAzYmEd on May 29, 2010, at 11:08:55
In reply to Re: 5HT2A is good! » CrAzYmEd, posted by Conundrum on May 29, 2010, at 10:50:27
"Interesting thread. Albeit kind of useless. First of all a lot of studies are done with rats, and humans do react different. Second my own experience with prozac reflects what Brainbeard said. At low doses I feel motivated on fluoxetine. As the dose is increased I no longer want to eat. Something has changed with the 5 HT2C receptor. "
Sure, more 5HT can cause more 5HT2C agonism, counteracting some antagonism of the 5HT2C receptor, but in HUMANS acute and chronic dosing of prozac increases plasma dopamine levels.
Besides that your own subjective experience doesnt say much about dopamine or serotonine, like i said a higher dose can counteract some 5HT2C antagonism, however that doesnt mean that your dopamine levels are decreased. Just that they MAY be less then on a lower dose, also serotonine can cause emotional blunting and apathy (atleast ssri's can cause that) so this may also overpower any other benefits.
"Finally, wouldn't a true agonist cause people to hallucinate?"
No, lisuride is the proof that this isnt the case, the 5HT2A receptor can be activated in differend ways, there's a differend downstream effect with hallucogenics.
Besides, i wouldnt call this thread useless.