Posted by linkadge on May 18, 2010, at 14:16:35 [reposted on May 20, 2010, at 18:36:21 | original URL]
In reply to Re: Gone with trimipramine, posted by bulldog2 on May 18, 2010, at 13:36:54
Trimipramine has the same opioid like effects as other TCA's. Even though it doesn't inhibit monoamine uptake, who says this matters?
Trimipramine has affniity for MAO-B as well as the DAT transporter. It also shares the common affinity for monoamine receptors (acetylcholine, serotonin, histamine etc.)
I would strongly hesitate in saying that surmontil is not an antidepressant just because it doesn't inhibit the classic monoamines (serotonin, norepinephrine).
After all, its this flawed logic that produces the so called "tianeptine paradox"
Linkadge
poster:linkadge
thread:948075
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/948079.html