Posted by bulldog2 on September 5, 2008, at 16:51:36
In reply to Inhibit Reuptake of Ser-Yes, Nor-Yes, but Dop-No?, posted by Fivefires on September 1, 2008, at 7:01:14
> Hey. It's 5f.
>
> I'm posting about the pharmacology and pharmacodynamics of venlafaxine (I know. That's just what I was thinking.) I copied and pasted a paragraph from
>
> http://www.realmentalhealth.com/medications/effexor.asp
>
> and it is as follows:
>
> <The mechanism of the antidepressant action of venlafaxine in humans is believed to be associated with its potentiation of neurotransmitter activity in the CNS. Preclinical studies have shown that venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), are potent inhibitors of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine reuptake. Venlafaxine and ODV have no significant affinity for muscarinic cholinergic, H1-histaminergic, or α1-adrenergic receptors in vitro. Pharmacologic activity at these receptors is hypothesized to be associated with the various anticholinergic, sedative, and cardiovascular effects seen with other psychotropic drugs. Venlafaxine and ODV do not possess monoamine oxidase (MAO) inhibitory activity.>
>
> Can someone tell me ... don't we need some inhibiting of the reuptake of Dopamine too? Why doesn't venlafaxine care about Dopamine? Did the company make a different med for it?
>
> (I wonder if trazodone inhibits the reuptake of dopamine? I ask because I can choose either trazodone or Soma.)
>
> What meds do inhibit the reuptake of Dopamine?
>
> Am I correct dopamine's job is to 'relax me' and serotonin's job is to 'make me feel happy'?
>
> And hey, just read a post over in Medications about serzone and/or Nefazodone. There was talk of it working like Effexor.(?) I believe the poster referred to it as a med that worked very well, after trying many that didn't.
>
> No one has ever mentioned serzone or Nefazodone to me. (I'm pouting.) So, there's another one I've not tried.
>
> My diagnoses are anyone's guess, except for the anxiety which way fits the bill. Currently we're going w/ Atypical Depression, but this looonnnggg Episode of Major Depression hasn't let up. Now PCP looking at mono, CFS, and Epstein-Barr. Iron, B12, other labs low.
>
> How do you get mono? I've never had it. Did my ex-sigother kiss someone else and then kiss me?:{
>
> Only thing I take besides Effexor-XR, Xanax-XR, Xanax, and levothyroxine, is Provigil. I think we'll be discussing augmenting Effexor-XR or going to the old Effexor and augmenting it, at appt in a little over a week.
>
> Augmentingt suggestions have been Remeron, amitriptyline, nortriptyline, and Lamictal.
>
> What is it with all the hooplaa over Lamictal? What is it w/ hoopla at all? I have none. Nada. I never get happy anymore.
>
> I tried Lamictal once and just got a headache.
>
> Pardon me for touching on a few different issues w/o any particular order here. If I tried to put this in order, I'd have to stand up and yell at my post, pointing and yelling at each paragragh, like I was Al Pacino, 'Your out of order!' 'Your out of order!' 'Your ALL out of order!'(?)
>
> It's the dosages of Effexor-XR make me shake my head. I only weight 112lbs, but if it's excreted in the urine, well ... I, pee, (I know you do to, but get a load of the following.) about every *30minutes* since had a total abdominal hysterectomy and bilateral oophorectomy (latter tubes and ovaries) and my bladder fell down in the big empty space (repaired but fell again) and I've developed a cystocele (it's like a pocket where urine (pee) gets stuck in there and you feel like you always have to go and you do. You kind of have to do weird body positions, like yoga on the toilet, and breathing like you're having a baby, to get it out. Yes I should have surgery again, but now it involves a piece of mesh and will fail if you become constipated and I would because I'm on a narcotic for a back injury, sooo I just keep putting off thinking about the whole thing.
>
> Anyway, what I want to say is 300mg is comfortable, but 375mg is very comfortable! Did I say, I'm little? I weigh 112lbs. and am 5'5". Anyone else take this much? I, and anyone I've ever spoken w/ about it, agree I am a fast or poor metabolizer, so I NEED MORE of a medication, especially those that hang out in body fat.
>
> I should be in bed. I couldn't sleep. I broke a 13yr relationship off tonight and the thrashing in my bed sort of scared me into thoughts like 'maybe this is when pp start hearing voices' and my feet hit the floor pretty quickly.
>
> Someone pls read this (You can do a quick scan; no one will ever know.) Humoring me would even be appreciated. Poor me. Poor, poor me. No! Poor him! Loser! Way poor him!
>
> Ex-boyfriend lied, a lot. Can't believe I stayed w/ him so long. Can you? There I go thinking 'it's all about me' again.
>
> Am I dissatisfied w/o being hurt? Think it could be so. Another issue plopped into the midst of this post. It involves last betrothed and injured.
>
> Moooo said the bull; ON said the cow!? o_o
>
> I meant to say, moooovvviinnngg ooonnnn...but thought that was funny. Maybe it isn't?
>
> Don't understand why Effexor didn't do something to block the reuptake of dopamine? (I don't think it should be capitalized.) What about uptake? There has to be uptake to be reuptake doesn't there? Is the dopamine, in this case, given two shots at getting to its proper destination? Uptake and then reuptake? What is the diff' of uptake and reuptake?
>
> When will there be an AD that blocks reuptake of serotonin, norepinephrine, and dopamine; the whole shabang?!
>
> tks&hopeuget2stayhome, 5fDidn't read the other posts but Parnate has a strong dopamine component.
poster:bulldog2
thread:849657
URL: http://www.dr-bob.org/babble/neuro/20080706/msgs/850533.html