Posted by Larry Hoover on March 24, 2008, at 10:35:47
In reply to Re: Parnate LD 50 [xxx]?, posted by britney27 on March 24, 2008, at 8:44:41
> Hi Larry, your original suggetion of less than xxxmg/kg does not refer to Tranylcypromine (parnate).
Oh, it does refer to Parnate. I just searched again, and I found two different Glaxo MSDS documents for this drug. The one dated in 2001 is the one I referred to. I just found one dated 2005, which simply states that "adverse effects might occur following ingestion". I had no idea there were two different documents floating around. I stopped looking after I found the first one.
> My original figure was correct. Double that for full toxicity (ref Goldfranks Toxicologic emergencies).
Okay. I don't have access to that volume.
> I think you were mistaken with moclobemide, another MAOI but reversible which is much much higher saftey threshold, the same amount that you suggested.
Again, no. But, whatever.
> I know rats are different primates but they do behave similarily to humans.
I'm a toxicologist, Britney. You can't assume that. Standard wisdom is to implement a 1,000-fold safety factor for converting rodent tox thresholds to human exposure recommendations. And that's the exact discrepancy factor we've been discussing. I cannot assure you, however, that this is the reason the two sources differ by a factor of 1000. That would be very negligent of me.
> I agree with you though that knowing the symptoms of toxicity is important but even then it gets confusing because I have had some of those symptoms before and told the chemist and she said it was normal side-effects, so knowing hte safest maximum dose is still an important indicator for responsible consumption.
Yes, those are the typical side effects that one might experience with a dose increase. The thing is, the body has to get past them before it can adjust/accomodate to them. Toxicity in this instance is an acute experience. Statistical evidence will not accurately predict individual experience.
> Thanks so much for your reply though, I really do appreciate the fact that you replied to my question.
>
> cheers
>
> BritneyYou're welcome.
Lar
poster:Larry Hoover
thread:819514
URL: http://www.dr-bob.org/babble/neuro/20080204/msgs/819644.html