Posted by Larry Hoover on March 23, 2008, at 22:45:44
In reply to Parnate LD 50 [xxx]?, posted by britney27 on March 23, 2008, at 8:12:43
> Hi,
>
> I am currently on Parnate and I am finding that it works really well but I have a tolerance towards it and I feel that I have to increase the dosage for it to remain effective. I have taken 100mg per day but read that it is possible to take up to 200mg a day but I am not sure if this is a safe dosage and whether it will cause hypertensive crisis or serotonin toxicity because I have read that the XXX.Uhhh, the Glaxo MSDS lists the oral LD50 in rats at "XXX". That's a substantial discrepancy from the figure you've presented.
In any case, what you need to do is familiarize yourself with the overdose symptoms for Parnate. The monograph lists those as: anxiety, agitation, manic symptoms, restlessness, mental confusion, insomnia and digestive disturbances. Beyond that, both hypertensive and hypotensive crisis (i.e. shock) can occur.
Lar
poster:Larry Hoover
thread:819514
URL: http://www.dr-bob.org/babble/neuro/20080204/msgs/819614.html