Posted by Jimmyboy on February 4, 2009, at 10:21:32
In reply to Re: ldn for autoimmune, perhaps with depression? » Phillipa, posted by tealady on February 4, 2009, at 3:47:29
Hi Tealady,
I just wanted to give you an update on my experience as well as with a few people I know who are taking ldn for various things.
First of all, a caveat, like many people on this particular board, i would say that I am not a "normal" responder ro many medications so keep that in mind. I tend to be pretty sensitive to whatever I am taking. With that being said..
I am still taking LDN, about 1.5-3 mgs 2-3 times/wk. The night I take it is always rough b/c it messes up my sleep but this supposedly goes away if you are taking it regularly. The reason I don't take it everyday is simply that I think I get TOO many endorphins if I dose it that way. Everyday dosing makes me feel a bit shaky and sort of spacy, so splitting up the dose has been the way for me to handle that. generally the day after I take it, I don't feel so great ( maybe b.c of lack of sleep the night before?) But the next few days after that I generally feel pretty great, definitely above baseline and it seems to gradually drop back down to baseline over the next few days. (sort of like a reverse hangover) - at that point I take another dose.
I am assuming any positives I have had are due to re-sensitizing (increasing density) my mu opiate receptors from the temporary blockade and not b/c a favorable change in my immune system response ( evening out TH1 to TH2 response which occurs on continuous LDN treatment - AKA why it works for MS and various other diseases).
So it makes sense in a way..Mu opiate receptor agonism a big trigger for "pleasure". if you can get more of these (upregulate)/make them more sensitive by a temporary blockade then you are going to be temporarily more likely to have natural endorphins activate them and cause pleasure. anyway, this is just my opinion.
As for others I know that LDn causes them to consistantly be more alert and awake in the morning early afternoon, but cause a "siesta effect" where they feel like they need to take a nap around 4pm or so.
Hope this helps.
poster:Jimmyboy
thread:877763
URL: http://www.dr-bob.org/babble/alter/20090204/msgs/877967.html