Posted by Larry Hoover on June 19, 2004, at 7:57:20
In reply to Re: GABA » Questionmark, posted by chemist on June 19, 2004, at 3:27:39
> hello there, chemist here... lar is spot-on. the entire question is quite moot, really: gamma butyric acid is water-soluble and lipid soluble, so crossing the BBB is not an issue. what is an issue is activating the GABA_{A} receptor and inducing chloride flux. if you take GABA and it works - as lar has said - then great. otherwise, there really is no need to go for it, as your GABA_A} (mostly) receptor needs to be inhibited by reuptake, so any additional flooding is not going to help unless you have a drug in the binding site that will inhibit...all the best, chemist
Dude, you raised more questions.
Both niacinamide and magnesium ions have been shown to increase GABA-ergic activity (my perhaps not totally correct/concise description). Do either/both of these qualify as "drug in the binding site"? I know both bind to the receptor, but not at the benzo site.
And that other point, about flooding. You're really saying that chronic dosing with oral GABA will not be as effective as taking it in pulses?
Thanks.
Lar
poster:Larry Hoover
thread:357170
URL: http://www.dr-bob.org/babble/alter/20040613/msgs/358041.html