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Re: Trimipramine undopaminergic

Posted by Jay2112 on December 17, 2022, at 17:33:20

In reply to Trimipramine SLS, posted by undopaminergic on December 17, 2022, at 8:22:37

> > I would also consider trimipramine. However, I don't have a clinical "feel" for trimipramine. Do you have any opinions regarding trimipramine?
> >
> I started trimipramine at 25 mg/day near the end of September 2019. It felt quite promising early on in treatment, and I often felt it was the best medication I've tried that is classified as an antidepressant. Now, I'm at 150 mg/day and it's been a long time, and I'm not really sure it is doing anything any more. The most promising signs came early in treatment, at very low doses. It did not get better with dose increments, but I'm not sure it got worse either.
> Pharmacodynamically, I find the most interesting action is histamine H2-receptor antagonism. Another interesting property is that it suppresses cortisol release acutely.
> It is a very strong antihistamine (H1-receptor), so it is best taken at night.
> -undopaminergic

Sounds similar to doxepin. But that stuff is thr strongest H1 antagonist available, I believe. I have NEVER had such a strong hangover effect as when I tried doxepin.

My late Dad had huge number of allergies, and really responded well to doxepin. He was on 300mg at bedtime, at one point. I DO respond well to anti-histamines, but doxepin, the hangover is just WOW!!


Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-




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poster:Jay2112 thread:1121195