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Re: Trimipramine undopaminergic

Posted by SLS on December 17, 2022, at 15:46:57

In reply to Trimipramine SLS, posted by undopaminergic on December 17, 2022, at 8:22:37

Hi, UD.

> > I would also consider trimipramine. However, I don't have a clinical "feel" for trimipramine. Do you have any opinions regarding trimipramine?
> >
> I started trimipramine at 25 mg/day near the end of September 2019. It felt quite promising early on in treatment, and I often felt it was the best medication I've tried that is classified as an antidepressant. Now, I'm at 150 mg/day and it's been a long time, and I'm not really sure it is doing anything any more. The most promising signs came early in treatment, at very low doses. It did not get better with dose increments, but I'm not sure it got worse either.
> Pharmacodynamically, I find the most interesting action is histamine H2-receptor antagonism. Another interesting property is that it suppresses cortisol release acutely.
> It is a very strong antihistamine (H1-receptor), so it is best taken at night.
> -undopaminergic

That's valuable information. Thanks.

Trimipramine was the second drug my current doctor tried on me. The first was doxycyline. He wanted to rule-out Lyme Disease. I don't remember if I was taking any other drugs at the time. It didn't make me feel worse, which by itself is a blessing. I don't remember dosages or the length of the trial. It didn't affect me one way or the other.

Do you think trimipramine helps at all by improving sleep architecture? I didn't know that it was so antihistaminergic.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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