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Re: Linkadge medication ed_uk

Posted by SLS on December 5, 2022, at 9:46:32

In reply to Re: Linkadge medication, posted by ed_uk on December 5, 2022, at 1:28:59

> Hi Scott,
> I don't know about that! Was more a suggestion based on something which might help, and which is often possible to obtain. These meds do appear to have been helpful before, except quetiapine.
> Link's symptoms are highly variable over time, as far as I can tell. As a result, I can see it being necessary to make changes in future. The response to antidepressants doesn't seem to have been stable.

I think it would be instructive to read my previous posts to Linkadge. They are scattered on the board, but they are easy to find. Prior to 2 years ago, I was where Linkadge and so many other sufferers are now. There is no way one could have predicted 3 years ago that two antidepressants and two adjuncts that are *commonly* used and are regarded by the medical community as being effective. This is demonstrated to clinicians by years of their own empirical observations of their patients and those related to them by their colleagues.

Sleep? I still have to use Ambien (zolpidem) for sleep a couple of times per week. I think that they are specific rather than selective for the benzodiazepine receptor subtype responsible for exerting hypnotic effects. Although I think Seroquel is wonderfully effective for sleep initiation + maintenane, I sometimes wonder what 25 mg of Seroquel does elsewhere in the brain. Personally, I would rather be on a drug that doesn't produce alterations in the dynamics of dopaminergic pathways. However, Seroquel would be my first choice if Z-drugs were ineffective. My experience with zolpidem is that the only adverse effect of abrupt discontinuation is a moderate rebound insomnia. There were absolutely none of the standard discontinuation side effects that are ubiquitious with standard benzodiazepines. It was strange not to have them.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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