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Re: 'anything can happen with psych drugs...' Jay2112

Posted by SLS on April 18, 2022, at 9:09:14

In reply to Re: 'anything can happen with psych drugs...' SLS, posted by Jay2112 on April 17, 2022, at 21:55:01

Hi, Jay.

Nice post. I'm glad you discovered so much about your unique responsivity to drug treatment. I really appreciate your descriptions.


> > Was clomipramine (Anafranil) among the drugs mentioned?
> >
> > In general, I think clomipramine is the strongest TCA. The side effects suck, though. You end up getting the side effects of both a TCA and SSRI, including sexual side effects.
> >
>
> Imipramine was...I believe it is on the WHO list of essential medications. Clomipramine makes me very sad, and cry heavily...for some odd reason. When my dog passed last year, I was on it, and cried constantly. Fluoxetine (Prozac) was able to slow that down.
>
> And amitriptyline, for me anyways, I think works well because of the strong anticholinergic properties. My hypersensitivity to choline seems quite evident. When I am really depressed, I get the slow, cold sweats, and inability to relax.
>
> But, I think we all get different and inconsistent results because of our biology. My Dad had a list of allergies a mile long, and responded well to doxepin, with it's powerful antihistamine properties. Now there are those DNA tests, regarding most effective drugs, with I think point in the right direction.


> Your experience with clorgyline sounds very interesting. It seems like certain drugs, even with the same mechanism of action, muck around to create a delicate balance that works in some, but not in others. I have this feeling we may start to see more money poured by drug companies back into psychiatry as diseases like Parkinson's and Alzheimer's explode with the aging population. (I'm already old...how long do we have to wait??..lol)
>
> I'd really like to get to this 'anything can happen' point with drugs...really. Nothing "bad" of course...but I think there is so, so, SO much more potential to be had. Like that article you posted Scott about a new, unrealized subset of serotonin receptors, was it? Or a drug that adjusts MAOI A and B, works on GABA, or the other many amines. I'd just wish that they'd hurry up with this stuff...or go back and pull some of the best of older drugs that may not work for person A, but K and Z respond well. (I still remember wanting to try protriptyline.)


Protriptyline exacerbated my depression tremendously. I don't know why (of course). If I recall properly, it is biased towards blocking norepinephrine reuptake. Reboxetine made my depression much worses. It's selective for inhibiting NE reuptake, I believe. That drug made me suicidal to the point where I told my parents that I was getting my affairs in order.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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poster:SLS thread:1119379
URL: http://www.dr-bob.org/babble/20220128/msgs/1119401.html