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Re: 'anything can happen with psych drugs...' undopaminergic

Posted by SLS on April 18, 2022, at 23:38:23

In reply to Re: 'anything can happen with psych drugs...' SLS, posted by undopaminergic on April 18, 2022, at 10:06:58

> >
> > Protriptyline exacerbated my depression tremendously. I don't know why (of course). If I recall properly, it is biased towards blocking norepinephrine reuptake.

> Like nortriptyline?

I really can't say. It think protriptyline might exert both NE reuptake inhibition and a strong anticholinergic effect. I have a tendency to focus on dopamine as being the common denominator in my case.

> > Reboxetine made my depression much worses. It's selective for inhibiting NE reuptake, I believe.

> It is. It relieved my emotional issues, by worsening my depersonalisation/derealisation, ie. it numbed my emotions. Permanently.

I am profoundly sad to know this. The risk we take with antidepressants is a reflection of how little we understand. In order to treat everyone effectively, we need to think of each brain as having a unique topography that must be mapped before choosing a path to follow.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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