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Re: 'anything can happen with psych drugs...' SLS

Posted by Jay2112 on April 17, 2022, at 21:55:01

In reply to Re: 'anything can happen with psych drugs...' Jay2112, posted by SLS on April 17, 2022, at 20:10:00

> > > > direct quote from my newest (professional, probably temporary) prescriber.
> > > >
> > > > what's the point, again?
> > >
> > > To find relief, as far as possible?
> > >
> > > -undopaminergic
> > >
> >
> > YES...that oh so desperate, sweet relief! That is really the heart of it all. I still remember, on the day of my first psych appointment. I was in such depressive tatters, soulfully exhausted on a scorching hot summer day in 1994. At about 4 in the afternoon, I took my first psych drug ever, lorazepam, and it was like the hand of god gently lay me into my bed. That evening, I took my first dose of amitriptyline, and I slept a sweet sleep that I so deeply needed. Like "st. joeseph's aspirin for the soul", as weeks went by, my life became, well, "LIFE", again.
> >
> > I still take amitriptyline (and other meds as well) to this day, and it is my absolutely MOST reliable medication!! A recent study found the drug to likely be the most reliable antidepressant available....with some give and take. But, 'tis life!
> >
> > Jay
> Was clomipramine (Anafranil) among the drugs mentioned?
> In general, I think clomipramine is the strongest TCA. The side effects suck, though. You end up getting the side effects of both a TCA and SSRI, including sexual side effects.

Imipramine was...I believe it is on the WHO list of essential medications. Clomipramine makes me very sad, and cry heavily...for some odd reason. When my dog passed last year, I was on it, and cried constantly. Fluoxetine (Prozac) was able to slow that down.

And amitriptyline, for me anyways, I think works well because of the strong anticholinergic properties. My hypersensitivity to choline seems quite evident. When I am really depressed, I get the slow, cold sweats, and inability to relax.

But, I think we all get different and inconsistent results because of our biology. My Dad had a list of allergies a mile long, and responded well to doxepin, with it's powerful antihistamine properties. Now there are those DNA tests, regarding most effective drugs, with I think point in the right direction.

Your experience with clorgyline sounds very interesting. It seems like certain drugs, even with the same mechanism of action, muck around to create a delicate balance that works in some, but not in others. I have this feeling we may start to see more money poured by drug companies back into psychiatry as diseases like Parkinson's and Alzheimer's explode with the aging population. (I'm already long do we have to wait??

I'd really like to get to this 'anything can happen' point with drugs...really. Nothing "bad" of course...but I think there is so, so, SO much more potential to be had. Like that article you posted Scott about a new, unrealized subset of serotonin receptors, was it? Or a drug that adjusts MAOI A and B, works on GABA, or the other many amines. I'd just wish that they'd hurry up with this stuff...or go back and pull some of the best of older drugs that may not work for person A, but K and Z respond well. (I still remember wanting to try protriptyline.)

Really, they could very likely save many, many lives, especially after all that is going on in this mad world.


Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-




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