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Re: ritanserin, pimavanserin, and lumateperone

Posted by undopaminergic on September 20, 2021, at 8:20:30

In reply to Re: ritanserin, pimavanserin, and lumateperone undopaminergic, posted by linkadge on September 19, 2021, at 16:10:43

> >venlafaxine does not attenuate the tyramine >pressor effect.
> I've heard that the in-vivo inhibition (by effexor) of the norepinephrine transporter is higher than would be indicated by traditional measures ...

I've heard that too. But it sounds to me like it may be marketing.

> and may point to an alternative binding site for effexor towards the norepinephrine transporter.

If it inhibits the noradrenaline transporter through some alternative binding site, wouldn't it inhibit the tyramine pressor effect?

> I had hypertension on effexor at 75mg.

Could it be, for example, an imidazoline receptor antagonist?

Or could it be a metabolite?





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