Posted by undopaminergic on September 10, 2021, at 17:27:42
In reply to Re: Best serotonin 5-HT2C antagonist?, posted by linkadge on September 10, 2021, at 16:54:14
> Clomipramine, to some degree is a 5-ht2c antagonist. Many of the TCAs are 5-ht2a/c antagonists.
>
> There are no available selective 5-ht2c antagonists. The closest is agomelatine, but I don't think this is available in the US.
>It is available here in Europe (EU). However, its half-life is only 1--2 hours, which does not sound useful:
https://en.wikipedia.org/wiki/AgomelatineI used it many years ago, but did not notice an effect.
> Others would include TCAs, mirtazapine, cyproheptadine and atypical antipsychotics.
>Yes. I'm thinking asenapine (Saphris, Sycrest):
https://en.wikipedia.org/wiki/AsenapineOf all receptors, it has the greatest affinity for 5-HT2C.
> I sometimes combine mirtazapine and cyproheptadine. I believe that mirtazapine is an inverse agonist which confers some additional properties over traditional antagonists.
>Asenapine is derived from mianserin like mirtazapine.
Last time I checked, sertindole was also an inverse agonist at 5-HT2C. I tried it, but had to cease it very soon due to extreme nasal congestion.
> A selective 5-ht2c antagonist would be quite useful (in my opinion).
>Yes, absolutely.
There are some used in research, and I tried to acquire them years ago, but failed.
-undopaminergic
poster:undopaminergic
thread:1116890
URL: http://www.dr-bob.org/babble/20210723/msgs/1116897.html