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Re: Studies:NSAIDS for depression (inflammation theory

Posted by linkadge on April 27, 2019, at 6:47:16

In reply to Re: Studies:NSAIDS for depression (inflammation theory, posted by Ruuudy on April 26, 2019, at 23:34:41

I believe it is possible for the brain to be in a state of high inflammation without necessarily having high markers of systemic inflammation. Often in depression / anxiety there is microglial activation, but this may not be best dealt with by taking NSAIDs. Also, there are many different immune cytokines that can become activated. There is likely not a complete overlap with conditions like arthritis. Keep in mind, drugs that aren't necessarily inflammation reducing can help lower brain inflammation. For example IL-1B is often elevated in depression / anxiety (at least in animal models). It decreases the brain's sensitivity to endocannabinoids. Green tea can apparently help normalize the levels of IL-1 when it is induced by stress. Minocycline (antibiotic) can also reduce microglial activation. You can google search "lowers il-1b" to get an idea of what may impact this inflammatory marker.

Linkadge


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