Posted by mtom on April 26, 2019, at 8:36:06
In reply to Re: Studies:NSAIDS for depression (inflammation theory » mtom, posted by linkadge on April 25, 2019, at 16:42:35
Most of the studies seemed to find Celecobix (Celebrex) was most effective. This is available only by prescription and most doctors might be reluctant to prescribe it as an antidepressant add-on, unless you show them the studies. Some studies it was given to people who had co-existing arthritis with depression. Some recommend testing for inflammation first, e.g. C-Reactive Protein. The Loyola study comments that other studies have found Celecobix beneficial as an add-on in doses up to 400 mg (my Dr won't prescribe more than 200). It does not say what dose Loyola used, it was also as an add on to escitalopram, and the study seem to be still in progress with "preliminary" results being reported so far: go to https://www.researchgate.net/publication/275115059_90_Inflammation_control_augments_antidepressant_response_in_bipolar_depression and click on Download PDF.
Many Doctors are still reluctant to prescribe Celecobix due to the Vioxx fiasco several years ago when Vioxx was pulled off the market. Because Celecobix is also a Cox-2 Inhibitor, it was presumed to have similar side effects - and doctors seem to prefer to prescribe Naproxen or Advil. However there have been several recent studies showing celecobix appears to in fact be safer than either Naproxen or Advil for GI, Cardiac and Kidney, and does not have the serious side effects of Vioxx.
I am also taking Omega-3's, eat very little sugar, and have been making sure to eat anti-inflammatory foods daily e.g. leafy greens, crucifers, blueberries, extra virgin olive oil, Turmeric, etc. and trying to avoid inflammatory foods e.g. deep fried, soy oil, and buy organic and naturally raised to the extent possible (not always a good variety available in Canada). Also trying to avoid gluten, difficult especially at social occasions. Eating more seafood.
I am also micro-dosing with CBD Oil, prescribed by a Doctor and provided by Government regulated and licensed Medical Cannabis producers here in Canada). Still take low dose escitalopram, without much beneficial effect and some side-effects continue. Hoping to wean off this at some point. Other AD's tried were worse.
Expect it could take a few months to notice any difference from all these, will see how it goes.
> The good news is that it is pretty easy to test the theory (i.e. to see if your depression is responsive to a reduction in inflammation).
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> You can see if your mood responds to anti-inflammatory medications. I would caution against aspirin (unless doctor supervised) since SSRIs and aspirin can synergistically thin the blood.
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> The omega-3s have significant anti-inflamatory effects and have been shown to augment standard anti-depressant medications. Diet can reduce inflamation too, i.e. reduce sugar, eat inflamation reducing foods.
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> Linkadge
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poster:mtom
thread:1104148
URL: http://www.dr-bob.org/babble/20190206/msgs/1104165.html