Posted by linkadge on April 26, 2019, at 16:24:17
In reply to Re: Studies:NSAIDS for depression (inflammation theory » linkadge, posted by mtom on April 26, 2019, at 8:36:06
I also have a medical marijuana card (in Canada). I have used both CBD and THC selective oils as well as a combination. In terms of inflammation, the THC is much more potent. The anti-inflammatory effects of cannabanoids are mostly through an activation of the CB2 receptors (which are located on immune cells). Of course, THC can have additional psychoactive effects.
I use a (relatively balanced) CBD / THC product with good results. The CBD alone wasn't quite potent enough. Of course, this is an individual decision.
There is evidence that many NSAIDs work ultimately via cannabinoid mechanisms. COX enzymes inhibit the synthesis of endocannabinoids.
You are right that Celebrex is the most studied, but there have been other positive effects of other meds. Google 'aspirin and mood'. I wouldn't lament it if your doctor won't prescribe celecoxib. Like I said, you can add other anti-inflammatories to your regiment, (just to see if your mood improves). Anti-inflammatory likely don't improve all depressions. If you positively respond however, you could bring this anecdotal information to your doctor, to discuss how you might move forward.
Linkadge
poster:linkadge
thread:1104148
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