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Re: Hoping Nardil kicks in at 60 (wk3) PeterMartin

Posted by SLS on April 20, 2018, at 10:43:08

In reply to Re: Hoping Nardil kicks in at 60 (wk3), posted by PeterMartin on April 20, 2018, at 9:00:17

> Nardil has been terrible for me.

In what ways?

> Maybe it's because I didn't do a washout from Marplan and thus didn't get a "kick in" effect I may have otherwise.

I doubt that this is the explanation. It is not unusual for people to get a euphoric reaction to Nardil in the beginning. You may have experienced an initial improvement due to factors that do not involve MAO inhibition. There must be something about Nardil that creates a state of arousal in a way not seen with Marplan or Parnate.

> 6wks of 60
> 6wks of 75

That's usually enough time to evaluate Nardil for efficacy. You could go up to 90 mg/day, but I wouldn't invest more than another 3 weeks at this dosage without trying an augmenting medication.

Are there any other medications that make sense for you to try next? Are MAOIs the only drugs that you respond to? Without knowing what you have tried in the past, it is difficult for one to suggest alternatives.

> I've had a few good periods of days on both dosages but it's been a while now.

This is an unfortunate truth about Nardil. It can produce an improvement or euphoric reaction briefly upon dosage changes. Some people chase the high and end up taking 120 mg/day and still be disappointed.

Have you discussed adding drugs to Nardil as augmenters?

> Scott (or anyone) have you ever tried Zonegran for weight loss as an adjunct?

I found Zonegran to suppress appetite to a moderate degree. It seemed like a rather clean drug otherwise. I can't remember it having any side effects.

Obviously, the easiest thing to do would be to try augmenting Nardil with another medication. Not too many doctors would go along with adding a TCA. Are there any drugs to which you had a partial response? I realize that you won't be able to add a serotonin reuptake inhibitor, but it would be helpful to have a list to refer to in the future.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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