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Re: How can I block Cortisol? » farshad

Posted by ed_uk2010 on March 25, 2018, at 9:52:36

In reply to Re: How can I block Cortisol?, posted by farshad on March 24, 2018, at 21:23:38

Hi,

>Its not the dopamine antagonism of the antipsychotic im out for its bcus it inhibits CRH.

Olanzapine (Zyprexa) acts at many receptors, so it's not possible to be so specific about why it can relieve agitation.

You said you found it calming before - after a single dose, I believe? That was probably due to action at multiple receptors, and not necessarily related to CRH.

>Is it just becuase it would be dangerous? Im willing to quit prami tho no problem... Im currently on 4 meds , I can quit the 3 I get online (prami, armmodafinil and selegline)

Taking strange combinations like pramipexole with olanzapine is really unknown territory. You don't want to make yourself more ill.

Pramipexole should not be stopped suddenly. Reduce gradually.

>and I get wellbutrin from my doc . So wellbutrin + zyprexa it will be then... But i doubt I will get zyprexa...

This is something you can speak to your doctor about. A lot of people find that olanzapine (Zyprexa) calms severe agitation after a small dose. Since a doctor has given it to you before, you can mention this.

For schizophrenia, olanzapine is taken every day. For relief of agitation in depressive illness, it is usually short-term.

A major issue with olanzapine is that some users gain a lot of weight.

>So I have to do a MRI scan for the CRF1?

No sorry, this wouldn't show on a MRI. Routine medical tests and scans do not show the function of this receptor.

As you know, there has been research into the possible role of CRF-1 receptors in mental health conditions . Much of the research has been on rats, but there have been some clinical trials in humans. As far as I can see, some trials showed possible evidence of efficacy, whereas others did not. As an example, a trial of pexacerfont, a selective CRF-1 receptor antagonist, found that it was not effective for generalised anxiety.

So, although a few CRF-1 antagonists have been developed by pharmaceutical companies such as GSK and BMS, it isn't entirely clear what they might be most useful for in humans.

 

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URL: http://www.dr-bob.org/babble/20180212/msgs/1097686.html