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Re: What Drug is the best serotonin receptor antagonis

Posted by farshad on January 23, 2018, at 8:57:58

In reply to Re: What Drug is the best serotonin receptor antagonis, posted by SLS on January 23, 2018, at 8:29:34

> Lamdage has a point regarding the difficulty of predicting what drugs will work to treat mental illness. I don't think neuroscientists can so precisely choose which drugs to try.
> You could be right, though. I wouldn't dismiss your ideas too quickly. There is a drug in France called tianeptine (Stablon) that does the opposite of SSRIs. It accelerates the reuptake of serotonin rather than inhibiting it. This presumably leaves less serotonin in the synaptic cleft (gap). Tianeptine has other properties that might account for its efficacy in treating depression, but I don't remember what they are. Keep in mind that a person can respond to one SSRI and yet have another make them feel worse. How do we explain that? Of course, there is an explanation. One day, it will become well-understood. Until then, we are limited to educated guesses and empirical observations (trial-and-error).
> - Scott

SSRI they decrease SERT ( serotonin transporter) in the first few weeks but after 6 weeks it starts to increase SERT above baseline and people feel relief . This would mean less serotonin is better since increasing SERT leads to less active serotonin.

Anywhow I have tried various methods .. Increase MAO.. Increase SERT... many methods... I have came to the conclusion I either have too many serotonin receptors or sensitive serotonin receptors IE they dont get disentized.. So this would mean my only soloution is to take an serotonin antagonist . Hence this thread.

So I have found the soloution to my problem.. My only question is is there a better serotonin antagonsit than Mianser or Mirtazapine? From what I can tell thats a no.. So im going for Mianserin....

I dont care what that lamdage guy says he doesent know my situation : Im not delusional.. I didnt come to the conclusion that serotonin is my problem in a day.. Its been years I have been trying various methods ...

Yes I tried tianeptine and it gave me some relief.... But my serotonin receptors need to be blocked for FULL relief.




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