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Re: What Drug is the best serotonin receptor antagonis

Posted by SLS on January 23, 2018, at 8:29:34

In reply to Re: What Drug is the best serotonin receptor antagonis, posted by farshad on January 23, 2018, at 5:17:06

Lamdage has a point regarding the difficulty of predicting what drugs will work to treat mental illness. I don't think neuroscientists can so precisely choose which drugs to try.

You could be right, though. I wouldn't dismiss your ideas too quickly. There is a drug in France called tianeptine (Stablon) that does the opposite of SSRIs. It accelerates the reuptake of serotonin rather than inhibiting it. This presumably leaves less serotonin in the synaptic cleft (gap). Tianeptine has other properties that might account for its efficacy in treating depression, but I don't remember what they are. Keep in mind that a person can respond to one SSRI and yet have another make them feel worse. How do we explain that? Of course, there is an explanation. One day, it will become well-understood. Until then, we are limited to educated guesses and empirical observations (trial-and-error).

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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