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Re: MAOI large doses MightyKondrian

Posted by SLS on October 16, 2017, at 10:37:01

In reply to Re: MAOI large doses PeterMartin, posted by MightyKondrian on October 16, 2017, at 6:13:43

> > How did you do on 150mg of Marplan? I take it but always have the 40-60 range. That's been good for me and I always seemed to get spacey when I tried 60 and 70.
> >
> >
> Well It creept up from 60 up to 120mg over 10yrs or more. The last couple yrs I went up to 150mg.
> All Hydrazine derivative MAOIs seem to have side effect that come on somewhat delayed. Then they last for anywhere from 3-9 months. but they always pass, eventually.
> My doc did say I have an unusual tolerance to Marplan. I'm hoping to (if the clonidine doesn't help) try up to increase my phenelzine to 150mg.
> Tranylcypramine is still on the cards but certainly not the time for that. I must ask him about Moclobemide or Selegiline. He said he'd be much more confident with most combinations. Then I can have lashings of different cheeses in my pizzas! :D
> MightyKondrian

Both the selegiline patch and moclobemide are treatments with low probabilities of being robustly or persistently effective. You will most likely feel very much better with moclobemide early in treatment - maybe within the first few days. This will probably last for a week to a month before you must continually increase the dosage to maintain an improvement up to a maximum of 1200 mg/day. Also, you really should consider consuming no more than 50 mg. of tyramine at any one meal. If I were you, I imagine I would try both treatments because I am desperate, and you never from where will come your healing. Because of this, I already tried both drugs. I guess I would try the selegiline patch first if moclobemide is not available in your country. However, the selegiline patch is not very effective until you get to 12 mg/24 hrs. At this dosage, selegiline becomes less selective and inhibits both MAO-A and MAO-B. In my estimation, it is the inhibition of MAO-A that exerts most of the antidepressant effect. So, it won't be a surprise if moclobemide makes you feel better at first. The ideal MAOI would be an irreversible and selective MAO-A inhibitor.

I hope one of these two drugs bring you to remission.

What drugs have you combined with Nardil so far?

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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