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Re: MAOI large doses MightyKondrian

Posted by SLS on October 14, 2017, at 20:07:34

In reply to MAOI large doses, posted by MightyKondrian on October 14, 2017, at 12:59:24

Nardil is a seductress. Be careful.

Regarding dosage, I would not go above 120 mg/day. Nardil is different from Parnate. Its kinetics are not linear. This is because it inhibits its own metabolism. So, doubling the dosage will yield more than a doubling of blood levels. I don't happen to know what the factor is, but it is probably exponential. When titrating, it is often suggested that one give at least 3 weeks for a particular dosage to work before considering an increase.

How long have you been taking Nardil at 120 mg/day? There are no guarantees, but some people don't respond to Nardil until they have been taking it for 12 weeks. Any kind of acute improvement in mood immediately after a dosage increase is unlikely to last. It does not surprise me that you caught a "buzz" from ingesting 120 mg of Nardil all at once. In my early experiences with Nardil, I found it mildly euphoric or stimulating immediately after every dose while taking 90 mg/day. I would guess that Nardil does more than just inhibit MAO oxidase and GABA transaminase. Perhaps there is something going on with dopamine release.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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