Posted by SLS on November 30, 2016, at 18:13:47
In reply to Re: Ketamine infusions for Depression, posted by Edward807 on November 30, 2016, at 10:47:38
Hi, Edward.
I have no idea if there is a commercially available test for BDNF genotypes. I never looked into it. I don't think there has been a prospective investigation to study the prognosticative value of testing for genotype in advance of ketamine treatment.
- Scott____________________________________________________
> > The dosage of ketamine is critical - (0.5 mg/kg) over 40 minutes. You can have IV infusions every day, but if the dosage is too low - or too high - it won't work for depression.
> >
> > With the frequency at which you are being given ketamine treatments, you should respond well, unless your genetics don't allow for this. The majority (66%) of people have the val66val allele for the BDNF (brain-derived neurotrophic factor) gene. These are the full remitters to ketamine. Then, there are those who have val66met. These people are partial responders only. The minority who have the met66met allele are non-responders.
> >
> > Are you allowed to take any other psychotropic drugs at this time? What about vitamins or food supplements?
> >
> > Also:
> >
> > val66val = SSRI responders
> >
> > val66met; met66met = SNRI or TCA responders
> >
> > I am wondering if those people with the met66met allele need MAOIs to achieve a robust antidepressant response - or perhaps a combination that would include Lamictal (lamotrigine), lithium, or Abilify (aripiprazole).
> >
> >
> > - Scott
>
> Hi Scott,
>
> I'm researching ketamine and found your post (I used to be active on this board years ago and just rejoined). How does one determine if they have the val66val allele for BDNF? Is there a particular test you would recommend? I've been reading about the GeneSight Psychotropic test.
>
> Thanks!
> Edward
>
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1086241
URL: http://www.dr-bob.org/babble/20160928/msgs/1093309.html