Posted by Edward807 on December 3, 2016, at 16:03:55
In reply to Re: Ketamine infusions for Depression » Edward807, posted by SLS on December 3, 2016, at 6:55:57
> Hi, Edward.
>
> Perhaps there advantages to using sublingual lozenges. Would you know?
>
> I think intranasal administration allows for ketamine to bypass the blood-brain barrier and reach its target sites more directly. Sublingual doesn't do this.
>
> If you can get enough ketamine in the brain to produce a mild dissociative state, then it is probsbly getting to where it needs to go.
>Hi Scott,
I agree, it would seem that intranasal administration would be more effective. Perhaps the lozenges they are using contain a larger dose of ketamine or the rate of absorption makes a difference.
Janssen Pharmaceuticals has several intranasal esketamine trials going on that I'm looking into.
Edward
poster:Edward807
thread:1086241
URL: http://www.dr-bob.org/babble/20160928/msgs/1093385.html