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Re: Ketamine infusions for Depression TJ_smith

Posted by SLS on February 18, 2016, at 14:45:34

In reply to Ketamine infusions for Depression, posted by TJ_smith on February 17, 2016, at 8:52:23

The dosage of ketamine is critical - (0.5 mg/kg) over 40 minutes. You can have IV infusions every day, but if the dosage is too low - or too high - it won't work for depression.

With the frequency at which you are being given ketamine treatments, you should respond well, unless your genetics don't allow for this. The majority (66%) of people have the val66val allele for the BDNF (brain-derived neurotrophic factor) gene. These are the full remitters to ketamine. Then, there are those who have val66met. These people are partial responders only. The minority who have the met66met allele are non-responders.

Are you allowed to take any other psychotropic drugs at this time? What about vitamins or food supplements?


val66val = SSRI responders

val66met; met66met = SNRI or TCA responders

I am wondering if those people with the met66met allele need MAOIs to achieve a robust antidepressant response - or perhaps a combination that would include Lamictal (lamotrigine), lithium, or Abilify (aripiprazole).

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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