Posted by SLS on June 7, 2015, at 12:58:03
In reply to Re: Replay: High cortisol = poor response to Prozac, posted by linkadge on June 7, 2015, at 12:04:17
> Yes, in general serotonergic agents do increase cortisol. I think the effect is mediated (in part) by 5-ht2 receptors. Reciprocally, cortisol increases the sensitivity of 5-ht2 receptors.
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> Some studies suggest a desensitization and / or normalization of cortisol over time, but others do not.
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> In general, agents with block 5-ht2a act as anti-cortisol agents. For instance, remeron, cyproheptadine, amitriptyline, seroquel etc have all been independently shown to decrease cortisol. In fact, cyproheptadine is a treatment for Cushings disease, characterized by hyper secretion of cortisol. Some of the antipsychotic (and perhaps augmentative) effect of atypicals is mediated by 5-ht2a.Great info. Thanks.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1079501
URL: http://www.dr-bob.org/babble/20150520/msgs/1079522.html