Posted by SLS on June 1, 2015, at 9:36:55
In reply to Re: Latuda. Need advices please! » SLS, posted by ihatedrugs1 on May 31, 2015, at 22:51:20
> A couple of years ago, I tried Remeron again, but it didn't do anything for depression nor help as a sleep aid like it did before.
Most doctors are clueless as to the true therapeutic dosage range for Remeron when treating severe depression. In my opinion, 45 mg/day is the minimum. Most doctors stop at 30 mg/day. Dumb. You don't start getting the antidepressant effect that comes from NE alpha-2 blockade at low dosages. Remeron is almost exclusively antihistaminic at dosages less than 45 mg/day. It does block a few serotonin receptors, but hypersomnia and hyperphagia prevail. Interestingly, there is a tendency for both of these effects to wane as the dosage is increased. In other words, although possibly effective for you, Remeron had no chance of working at low dosages.
Has the bipolar spectrum ever been discussed with you as a possible diagnosis?
If you were responsive to treatment at one time, I would not capitulate to pessimism or cynicism just yet. Even when you lose optimism, resilience, and positive energy, try to be constructive rather than ruminating and projecting negative energy. It might help you from finding yourself in dark places.
Don't give up.
I am doing pretty well so far today (all things considered). Thanks for asking :-) I am grateful for a reprieve from the worst of it.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1079315
URL: http://www.dr-bob.org/babble/20150520/msgs/1079366.html