Posted by ihatedrugs1 on May 31, 2015, at 20:33:47
In reply to Re: Latuda. Need advices please! » ihatedrugs1, posted by SLS on May 30, 2015, at 9:22:16
> > Latuda didn't help with sleep nor my (unipolar) hard to treat depression.
> >
> > Best of luck,
> > ihatedrugs
>
> Despite having had the promise of producing robust antidepressant effects, I am disappointed with the numbers of people on Psycho-Babble who have responded well to Latuda. It should be noted that its major metabolite is an antagonist at NE alpha-2 receptors - similar to Remeron. I was not surprised that I felt worse on Latuda. Both Remeron and idazoxan (an investigational drug) exacerbate my depression (bipolar). Believe it or not, the major metabolite of Buspar also blocks NE alpha-2 receptors. Perhaps this property accounts for its reputation to act as an augmenting agent to antidepressants. Certainly, 5-HT1a partial agonism has not shown robust antidepressant activity (Viibryd; Brintellix).
>
> Two people here have reacted badly to Saphris with a worsening of depression, including me. However, I have seen it work wonders as an antidepressant in schizoaffective disorder It can have a positive effect on sleep - at least in the beginning. I have not seen it produce weight gain nor sedation beyond the startup period.
>
>
> - Scott
>Interesting. I did respond to Remeron but its weight gain side effects prompted me to quit. This was years ago. I tried Saphris but it didn't work either and gave me severe akathisia. I'm on Abilify 2mg which works for the agony aspect of my depression, but produces restlessness which I try to tolerate. I'm also taking Effexor 150, Wellbutrin 300, Vyvanse 40 mg, and for sleeping Xanax, Gabapentin Trazodone and Ambien. Despite these many meds I still feel blah; no motivation, no interest in things I used to love doing and severe fatigue.
Be well,
ihatedrugs
poster:ihatedrugs1
thread:1079315
URL: http://www.dr-bob.org/babble/20150520/msgs/1079360.html