Posted by SLS on May 30, 2015, at 9:22:16
In reply to Re: Latuda. Need advices please!, posted by ihatedrugs1 on May 30, 2015, at 3:17:03
> Latuda didn't help with sleep nor my (unipolar) hard to treat depression.
>
> Best of luck,
> ihatedrugsDespite having had the promise of producing robust antidepressant effects, I am disappointed with the numbers of people on Psycho-Babble who have responded well to Latuda. It should be noted that its major metabolite is an antagonist at NE alpha-2 receptors - similar to Remeron. I was not surprised that I felt worse on Latuda. Both Remeron and idazoxan (an investigational drug) exacerbate my depression (bipolar). Believe it or not, the major metabolite of Buspar also blocks NE alpha-2 receptors. Perhaps this property accounts for its reputation to act as an augmenting agent to antidepressants. Certainly, 5-HT1a partial agonism has not shown robust antidepressant activity (Viibryd; Brintellix).
Two people here have reacted badly to Saphris with a worsening of depression, including me. However, I have seen it work wonders as an antidepressant in schizoaffective disorder It can have a positive effect on sleep - at least in the beginning. I have not seen it produce weight gain nor sedation beyond the startup period.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1079315
URL: http://www.dr-bob.org/babble/20150520/msgs/1079334.html