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Re: Nardil or Marplan?

Posted by SLS on May 12, 2014, at 14:37:20

In reply to Re: Nardil or Marplan?, posted by tom2228 on May 12, 2014, at 13:30:11

Nice synopsis, Tom.

- Scott

> I have been on all 3 and Marplan is my favorite.
> Marplan makes me feel like myself (it is supposedly good for depersonalization/ dissociative symptoms) and allows me to be more in touch with memories of how I've felt throughout the years.
> I consider Marplan to be the cleanest. In general I find it to be relatively low on side effects. Some do say that the other two have more "umph" for depression, but that's a matter of subjectivity.
> - Mechanism wise it is the closest to a pure MAOI
> --Nardil has effects on GABA transaminase and phenylethylamine as a metabolite;
> --Parnate is stronger on MAOI-B and has an effect on GABA-B;
> --Marplan has has less-pronounced effects on dopamine beta-hydroxylase and tryptophan metabolism, although it "feels" the closest to a pure MAOI)
> -whereas the other two can have sedation problems, Marplan seems to be neutral to some and activating to others (I find it pretty stimulating at 40mg and over)
> -Marplan lacks, or is more forgiving in terms of the afternoon sleepiness you speak about
> -Marplan tends to be weight-neutral (whereas Nardil is is known of weight gain)
> -Sexual side-effects are not as bad a Nardil in my experience
> -The insomnia is nowhere near the insomnia on Parnate, I've found.

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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