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Cymbalta vs Pristiq

Posted by klein on April 23, 2014, at 12:30:37

Hi everyone - I'm new here.

I've been on a small dose of Zoloft for a couple of years now for MDD. My mood is okay but I still feel lethargic. After trying Provigil and assorted amphetamines, my doc decided to add an SNRI.

First came Effexor at different dosages over the course of several months (dosage range from 37.5 to 300+, tried both XR and IR and a combination of the two). It was activating at times but not consistent.

Then we tried Savella (dosage range from 12.5mg to 200mg) to see if it worked better. Knowing about the NE hit, I had high hopes but it turned out to be ineffective for my needs, it made me feel incredibly drowsy and even more lethargic. The drowsiness got worse every time the dose was increased.

So now he wants to try Cymbalta. I'm a bit leery as (I think) duloxetine seems to be more similar to Savella than to Effexor.

I know it's all about trial + error but, given that I did relatively well on Effexor, I'm wondering if Pristiq might be a better choice to try next.

Any thoughts? Thanks!


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