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Re: How can the half-life of Marplan be unknown? SLS? PeterMartin

Posted by SLS on March 10, 2014, at 7:59:27

In reply to Re: How can the half-life of Marplan be unknown? SLS?, posted by PeterMartin on March 10, 2014, at 1:09:08

> Fantastic reply - thanks.
> The suggestion to take it twice a day is probably what I was after. My doc is the type that says if it makes you tired take it at night, if it keeps you up take it in the morning.....kinda leaves it up to me. I've been taking it since 2010 but I responded well to 20mg when it was added to my lamictal/seroquel regime. At some point I went up to 30mg. I've always taken it as one dose at night.
> Ive had some breakthrough depression the last few months so I've been trying 40 and now 50mg over the past month. Since it only comes in 10mg I decided to try the extra 10/20mg in the morning and continue to take 30 at night. Doing that though the last few days I've had flashes of feeling good followed by really spacey/down periods. I'd like to give the dose a fair trial over a period of weeks as my body is probably just adjusting. Im justbhoping to have at least a little logic behind either dividing or taking it all at night. I'll probably stick with this (30 at night / 20 in the am) for another few weeks and see how it goes.
> Still bizarre to me that there isn't more data about how long it takes to break down.
> Appreciate the quick reply. Have read many of your posts since 2005 and love your insight.

If taking Marplan all at once in the evening works for you, and your burden of side effects remains minimal, I don't know of any reason why you cannot do this. I have heard of people taking Parnate once a day. I am a bit of a stickler for maintaining a constant blood level, but this may not always be that important. Parnate must produce a peak concentration in the brain very quickly. It enters, binds irreversibly, and disappears out of the blood stream, leaving behind the inactivated enzymes permanently disabled. (There is some debate about the absolute irreversibility of Parnate). Personally, I like to see a drug have a half-life of 18 or more hours before dosing once a day. This is arbitrary on my part, though. Lamictal has a half-life of 25 hours (when given without enzyme inducers or inhibitors), but I don't feel right unless I take it twice a day.

I hate to see you push yourself through several weeks of feeling spacy with twice-a-day dosing if once-a-day dosing would be better. I will say this, though. Feeling spacy is often a prelude to my responding to Nardil. This could be happening to you, now that you have increased the dosage. For me, feeling weird can be a good thing. Also, insomnia has always been a good sign. I wish I had responded well to Marplan. It really was clean compared to Nardil and Parnate.

Good luck.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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