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Re: How can the half-life of Marplan be unknown? SLS? PeterMartin

Posted by SLS on March 10, 2014, at 0:38:51

In reply to How can the half-life of Marplan be unknown? SLS?, posted by PeterMartin on March 10, 2014, at 0:16:52

> I've searched all over and am unable to find the half life for Marplan. Whether it matters or not (Re: a previous thread here about this said halflife shouldn't matter w irreversible maois) isn't hakf-life standard drug information? The drug has has been around since the 60s.....
> Sorry to tag you specifically SLS but I love your insight on this forum. I also remember you did a trial of it a little while back. Any guesses?

I could not find the half-life of Marplan when I added it to my drug chart. As you know, Marplan and Nardil are both hydrazine compounds. Parnate is not. Parnate has a half-life of 1 - 3 hours. Nardil has a half-life of at least 12 hours after a single dose. However, Nardil inhibits its own metabolism because it inhibits MAO. At equilibrium, my guess is that the half-life of Nardil is significantly longer. Does this also occur with Marplan, taking into consideration that, like Nardil, it is a hydrazine? I don't know.

I would take Marplan at least twice a day to help avoid side effects. I found Marplan to be a remarkably "clean" drug. I hardly knew that I was taking it. Unfortunately, my response to it was inadequate, and I ultimately discontinued it.

I hope this was helpful. What was your reason for wanting to know the 1/2 life of Marplan?

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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