Posted by uncouth on December 20, 2013, at 12:43:58
In reply to Re: Amisulpride plus Pramipexole? » Uncouth, posted by SLS on December 19, 2013, at 21:03:24
Thanks Scott.
I know "lower dosages are more prodopaminergic", but that's usually comparing 25-100 vs 400+. Does that also hold when comparing say 100mg to 25mg? That part doesn't make sense to me, seems like at that level, a higher dose, up to some limit, will further antagonize presynaptic. I will probably start at 50mg...the real point of my original question I guess is -- which direction do I go from there if the effect isn't strong or sustained?Why aren't you impressed with pramipexole? What has been your experience, and at what dose?
I have already been taking Mirapex ER 2.25 mg for about the past 6 weeks. To limited effect, though the more I read about it, the more I feel like perhaps this is still a low dose for BP 2 (depression) and for general hypodopamergic state as it may still be operating too presynaptically. But honestly, who knows? I can't profess to have this level of self-insight into my neuronal activity! Never had sleep attacks.
So I guess given that I'm already on mirapex, want to be a bit cautious about adding amisulpride, and would want to start with a conservative dose---which is why I ask whether starting at 25mg would be more "risky" in combo with mirapex than 100mg.
I am based in the US, so of course my psych doesn't have experience or much knowledge of amisulpride.
In addition, I want a high enough dose to get effective 5ht7 effects as I have significant sleep and cognitive issues I'm hoping are helped.
I can't remember too many details regarding my Abilify experiene, but i've been on it a number of times in the past 9 years, mostly at the 5-15mg range. Definite side effects of akithisia which I can't recall if they ever abated 100%. If I remember correctly, I probably took it as long as 6-12 months at one particular time. Also can't recall improvement, but my bias would be to say yes. However my symptoms have changed over the years.
I am bipolar 2/3, have rare hypomanias, more frequent mixed/irritable/compulsive/"racing thought" states but usually in teh summer. Higher dose A/P are too flattening and demotivating. And weight gain always tends to be an issue with A/Ps, though I also can't recall specifically my experience with abilify.
To be honest, the biggest concern I'd have with dopaminergics would be enhancement of impulsivity/compulsivity (e.g. gambling, sexual disinhibition, and especially internet addiction).
Thanks
UncouthP.S.-- curious as to what you are on these days? i Seem to remember last time I actively checked this forum you had a really good response to something very non-traditional (minocycline?). Have you achieved anything close to remission or improvement in your cognitive symptoms?
poster:uncouth
thread:1056502
URL: http://www.dr-bob.org/babble/20131209/msgs/1056616.html