Posted by SLS on December 19, 2013, at 21:03:24
In reply to Re: Amisulpride plus Pramipexole?, posted by Uncouth on December 19, 2013, at 13:28:09
The dosages of amisulpride, when used specifically for dysthymia or depression, is 25 - 100 mg/day.
Amisulpride binds much more readily and tightly to presynaptic dopamine receptors than postsynaptic receptors. The lower dosages of amisulpride therefore are more pro-dopaminergic than higher dosages. Although I am not impressed with pramipexole for depression - either alone or in combination with other agents. However, amisulpride (and sulpiride) might be a special combination to help re-regulate the dopamine neuronal synapse.
I would start amisulpride first and try to establish a dosage of 50 mg/day. Then, you can add pramipexole. If you experience unacceptable side effects (particularly sleep-attacks), you will know that the pramipexole is responsible for them.
Abilify:
1. What dosage?
2. What side effects?
2. How long?
3. Improvement?If bipolar disorder is not an issue, dosages of Abilify as an augmenter to antidepressants are 2.5 - 5.0 mg/day.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1056502
URL: http://www.dr-bob.org/babble/20131209/msgs/1056589.html