Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

D-amphetamine (Dexedrine; Adderal) = Serotonin? » linkadge

Posted by SLS on May 2, 2012, at 7:05:49

In reply to Re: creepy, posted by linkadge on May 1, 2012, at 17:02:57

Hi Linkadge.

All in all, most of the literature I found states that amphetamine releases serotonin. You were right (as usual).

I found some referenced literature on Wiki indicating serotonin release is a property of d-amphetamine. Unfortunately, the conclusions reached in these investigations rely upon inferences based on indirect in vivo observations using pharmacological probes rather than direct in vitro measurements using synaptosomes.

The following study is interesting:

http://www.ncbi.nlm.nih.gov/pubmed/21615721

It reported actual measurements of serotonin concentrations in response to different drugs. Amphetamine was the weakest at increasing extracellular serotonin. This is not an insignificant finding. However, again, it is an in vivo measurement. It is possible that this measurement represents an indirect increase of serotonin activity resulting from negative feedback loops that are wired to attenuate hyperlocomotion

http://www.ncbi.nlm.nih.gov/pubmed/15545015

Obviously, I am cherry-picking.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:SLS thread:1016758
URL: http://www.dr-bob.org/babble/20120425/msgs/1016924.html